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594 Denton Pl.
Middlesex, NJ  08846
(732) 648 8027

Objective: Advancing my career at Merck & Co., Inc.  
Experience: Catalysis Laboratory, Department of Process Research & Development, Merck & Co., Inc., Rahway, NJ  
Associate Principal Scientist, Chemistry 6/16 - present
Senior Scientist, Chemistry 8/12 - 5/16
Research Chemist 10/08 - 7/12
Staff Chemist 9/06 - 9/08
  • Supported all phases of drug discovery and development pipeline with innovative, timely, industry-leading catalytic chemical processes implemented on mg to 100+ kg scale
  • Became departmental expert in asymmetric hydrogenation through work on over 40 projects
  • Developed fundamental research program in precious and base metal-catalyzed asymmetric hydrogenation encompassing internal research and external academic collaborations
  • Managed high-throughput experimentation laboratory for asymmetric catalysis and gas reactions
  • Mentored colleagues, visiting scientists, postdoctoral researchers, and summer interns
Ivy Tech State College, Lafayette, IN 8/04 - 5/06
Adjunct Professor
  • Taught nine sections of introductory, general, and organic chemistry lecture and laboratory courses over five semesters
  • Designed and prepared instrumental and wet chemistry laboratory experiments
  • Developed course material for new general chemistry course
  • Developed online material to supplement course work
University of Illinois at Chicago, Chicago IL 8/01 - 4/04
Teaching / Research Assistant
  • Developed a concise synthesis of polyoxamic acid using a chelation-controlled Strecker reaction
  • Procured solvents, reagents, and common laboratory supplies for a twenty-person research group
  • Taught five laboratory and seven recitation sections of organic chemistry over five semesters
  • Delivered lectures for professors in absentia
  • Wrote quizzes, proctored examinations, and graded exams, quizzes, homework, and labs
  • Provided supplementary information on the internet to assist learning outside the classroom
Rose-Hulman Department of Chemistry, Terre Haute IN 3/00 - 6/01
Teaching Assistant
  • Taught two laboratory sections of analytical chemistry
  • Graded examinations, quizzes, lab reports, and homework for general and organic chemistry
  • Operated the NMR spectrometer for four laboratory sections of organic chemistry
Central States Analytical, Evansville IN 6/00 - 8/00
Analytical Chemist
  • Developed and verified HPLC methods for nutritional supplements and pharmaceuticals
  • Performed routine HPLC analysis of pharmaceuticals, wastewater samples, and vitamins
  • Performed lab work and maintained documentation in accordance with GLP guidelines
Rose-Hulman Instructional Services, Terre Haute IN 8/98 - 3/00
Audio-Visual Technician
Advanced Audio Concepts, Evansville IN 8/92 - 8/98
Audio Engineer
  • Produced live audio for concerts, conventions, and meetings
  • Operated a digital multitrack recording studio
  • Installed new equipment and serviced old equipment
Education: University of Illinois at Chicago, Chicago, IL GPA 4.00 / 4.00
Ph.D. Organic Chemistry, December 2020
Dissertation: Unlocking the Potential of N-O Bonds in Organic Synthesis
University of Illinois at Chicago, Chicago, IL GPA 4.00 / 4.00
M.S. Organic Chemistry, July 2004
Rose-Hulman Institute of Technology, Terre Haute, IN GPA 3.67 / 4.00
B.S. Chemistry, minor in Chemical Engineering magna cum laude, May 2001
Indiana Academy for Science, Mathematics and Humanities, Muncie, IN
Indiana Academic Honors Diploma, May 1998
Related Courses: Advanced Organic Chemistry, Organic Structure Determination, Synthetic Organic Chemistry, Theoretical Organic Chemistry, Peptide Synthesis, Biochemistry, Advanced Inorganic Chemistry, Analytical Chemistry, Physical Chemistry, Glassblowing, Material and Energy Balances, Fluid Mechanics, Heat Transfer, Mass Transfer, Materials Science  
  • High-throughput experimentation, transition metal catalysis, glovebox techniques, HPLC, SFC, GC, preparative chromatography, NMR, IR, organic synthesis, statistical design of experiments
  • Symyx LEA, Insight II, Gaussian 98, Cerius2, Spartan, Chemdraw, Design Expert, Maple, Matlab, C++, C, Java, HTML, CSS, Linux, Windows, IRIX, DOS, Word, Excel, Powerpoint, Access
  • Skilled in the operation, maintenance, and repair of electronic equipment and instrumentation
  • Adept in the classroom, teaching laboratory, and research laboratory
  1. MacNeil, C. S.; Zhong, H.; Pabst, T. P.; Shevlin, M.; Chirik, P. J.  Cationic Bis(phosphine) Cobalt(I) Arene Complexes as Precatalysts for the Asymmetric Synthesis of SitagliptinACS Catal. 2022, 12, 4680-4687.
  2. Nepal, P.; Kalapugama, S.; Shevlin, M.; Naber, J. R.; Campeau, L.-C.; Pezzetta, C.; Carlone, A.; Cobley, C. J.; Bergens, S. H. Polycationic Rh-JosiPhos Polymers Supported on Phosphotungstic Acid/Al2O3 by Multiple Electrostatic AttractionsACS Catal. 2022, 12, 2034-2044.
  3. Zhong, Y.-L.; Moore, J. C. ; Shevlin, M.; Shultz, C. S.; Kosjek, B.; Chen, Y.; Janey, J. M.; Tan, L.  Scalable Asymmetric Synthesis of MK-8998, a T-Type Calcium Channel AntagonistJ. Org. Chem. 2022, 87, 2120-2128.
  4. Klapars, A.; Chung, J. Y. L.; Limanto, J.; Calabria, R.; Campeau, L.-C.; Campos, K. R.; Chen, W.; Dalby, S. M.; Davis, T. A.; DiRocco, D. A.; Hyde, A. M.; Kassim, A. M.; Larsen, M. U.; Liu, G.; Maligres, P. E.; Moment, A.; Peng, F.; Ruck, R. T.; Shevlin, M.; Simmons, B. L.; Song, Z. J.; Tan, L.; Wright, T. J.; Zultanski, S. L.  Efficient Synthesis of Antiviral Agent Uprifosbuvir Enabled by New Synthetic MethodsChem. Sci. 2021, 12, 9031-9036.
  5. Shevlin, M.; Strotman, N. A.; Anderson, L. L.  Concise Synthesis of Furo[2,3-b]Indolines via [3,3]-Sigmatropic RearrangementSynlett 2021, 32, 197-201.  Invited contribution to special cluster on Heterocycle Synthesis and Functionalization.
  6. Schuster, C. H.; Dropinski, J. F.; Shevlin, M.; Li, H.; Chen, S.  Ruthenium-Catalyzed Enantioselective Hydrogenation of HydrazonesOrg. Lett. 2020, 22, 7562-7566.
  7. Zhong, H.; Shevlin, M.; Chirik, P. J.  Cobalt-Catalyzed Asymmetric Hydrogenation of α, β-Unsaturated Carboxylic Acids by Homolytic H2 CleavageJ. Am. Chem. Soc. 2020, 142, 5272-5281.
  8. Chung, J. Y. L.; Meng, D.; Shevlin, M.; Gudipati, V.; Chen, Q.; Liu, Y.; Lam, Y.-H.; Dumas, A.; Scott, J.; Tu, Q.; Xu, F.  Diastereoselective FeCl3·6H2O/NaBH4 Reduction of Oxime Ether for the Synthesis of β-Lactamase Inhibitor RelebactamJ. Org. Chem. 2020, 85, 994-1000.
  9. Molinaro, C.; Phillips, E. M.; Xiang, B.; Milczek, E. M.; Shevlin, M.; Balsells, J.; Ceglia, S.; Chen, J.; Chen, L.; Chen, Q.; Fei, Z.; Hoerrner, S.; Qi, J.; de Lera Ruiz, M.; Tan, L.; Wan, B.; Yin, J.  Synthesis of a CGRP Receptor Antagonist via an Asymmtric Synthesis of 3-Fluoro-4-aminopiperidineJ. Org. Chem. 2019, 84, 8006-8018.
  10. Zhong, Y.-L.; Cleator, E.; Liu, Z.; Yin, J.; Morris, W. J.; Alam, M.; Bishop, B.; Dumas, A. M.; Edwards, J.; Goodyear, A.; Mullens, P.; Song, Z. J.; Shevlin, M.; Thaisrivongs, D. A.; Li, H.; Sherer, E. C.; Cohen, R. D.; Yin, J.; Tan, L.; Yasuda, N.; Limanto, J.; Davies, A.; Campos, K. R.  Highly Diastereoselctive Synthesis of a HCV NS5B Nucleoside Polymerase InhibitorJ. Org. Chem. 2019, 84, 4780-4795.
  11. Friedfeld, M. R.; Zhong, H.; Ruck, R. T.; Shevlin, M.; Chirik, P. J.  Cobalt-Catalyzed Asymmetric Hydrogenation of Enamides Enabled by Single Electron ReductionScience 2018, 360, 888-893.
  12. Krska, S. W.; DiRocco, D. A.; Dreher, S. D.; Shevlin, M.  The Evolution of Chemical High-Throughput Experimentation To Address Challenging Problems in Pharmaceutical Synthesis. Acc. Chem. Res. 2017, 50, 2976-2985.
  13. Hyde, A. M.; Zultanski, S. L.; Waldman, J. H.; Zhong, Y.-L.; Shevlin, M.; Peng, F.  General Principles and Strategies for Salting-Out Informed by the Hofmeister SeriesOrg. Process Res. Dev. 2017, 21, 1355-1370.
  14. Shevlin, M; Guan, X.; Driver, T. G.  Iron-Catalyzed Reductive Cyclization of o-Nitrostyrenes Using Phenylsilane as the Terminal Reductant.  ACS Catal. 2017, 7, 5518-5522.
  15. Shevlin, M.  Practical High-Throughput Experimentation for Chemists.  ACS Med. Chem. Lett. 2017, 8, 601-607.  Invited contribution to ACS Medicinal Chemistry Letters Innovations series.
  16. Humphrey, G. R.; Dalby, S. M.; Andreani, T.; Xiang, B.; Luzung, M. R.; Song, Z. J.; Shevlin, M.; Christensen, M.; Belyk, K. M.; Tschaen, D. M.  Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction.  Org. Process Res. Dev. 2016, 20, 1097-1103.
  17. Chung, J. Y. L.; Shevlin, M.; Klapars, A.; Journet, M.  Asymmetric Synthesis of N-Boc-(R)-Silaproline via Rh-Catalyzed Intramolecular Hydrosilylation of Dehydroalanine and Continuous Flow N-AlkylationOrg. Lett. 2016, 18, 1812-1815.
  18. Chung, C. K.; Cleator, E.; Dumas, A. M.; Hicks, J. D.; Humphrey, G. R.; Maligres, P. E.; Nolting, A. F.; Rivera, N.; Ruck, R. T.; Shevlin, M.  A Synthesis of a Spirocyclic Macrocyclic Protease Inhibitor for the Treatment of Hepatitis COrg. Lett. 2016, 18, 1394-1397.
  19. Shevlin, M.; Friedfeld, M. R.; Sheng, H.; Pierson, N. A.; Hoyt, J. M.; Campeau, L.-C.; Chirik, P. J.  Nickel-Catalyzed Asymmetric Alkene Hydrogenation of α,β-Unsaturated Esters: High-Throughput Experimentation-Enabled Reaction Discovery, Optimization, and Mechanistic ElucidationJ. Am. Chem. Soc., 2016, 138, 3562-3569.
  20. Friedfeld, M. R.; Shevlin, M.; Margulieux, G. W.; Campeau, L.-C.; Chirik, P. J.  Cobalt-Catalyzed Enantioselective Hydrogenation of Minimally Functionalized Alkenes: Isotopic Labeling Provides Insight into the Origin of Stereoselectivity and Alkene Insertion Preferences.  J. Am. Chem. Soc. 2016, 138, 3314-3324.
  21. Christensen, M.; Nolting, A.; Shevlin, M.; Weisel, M.; Maligres, P. E.; Lee, J.; Orr, R. K.; Plummer, C. W.; Tudge, M. T.; Campeau, L.-C.; Ruck, R. T.  Enantioselective Synthesis of α-Methyl-β-cyclopropyldihydrocinnamatesJ. Org. Chem. 2016, 81, 824-830.
  22. Molinaro, C.; Scott, J. P.; Shevlin, M.; Wise, C.; Menard, A.; Gibb, A.; Junker, E. M.; Lieberman, D.  Catalytic, Asymmetric, and Stereodivergent Synthesis of Non-Symmetric β,β-Diaryl-α-Amino AcidsJ. Am. Chem. Soc. 2015, 137, 999-1006.
  23. Buitrago Santantilla, A.; Regalado, E. L.; Pereira, T.; Shevlin, M.; Bateman, K.; Campeau, L.-C.; Schneeweis, J.; Berritt, S.; Shi, Z.-C.; Nantermet, P.; Liu, Y.; Helmy, R.; Welch, C. J.; Vachal, P.; Davies, I. W.; Cernak, T.; Dreher, S. D.  Nanomolar-Scale High-Throughput Chemistry for the Synthesis of Complex MoleculesScience 2015, 347, 49-53.
  24. Hoyt, J. M.; Shevlin, M.; Margulieux, G. W.; Krska, S. W.; Tudge, M. T.; Chirik, P. J.  Synthesis and Hydrogenation Activity of Iron Dialkyl Complexes with Chiral Bidentate PhosphinesOrganometallics 2014, 33, 5781-5790.  Invited contribution to special issue on Catalytic and Organometallic Chemistry of Earth-Abundant Metals.
  25. Friedfeld, M. R.; Shevlin, M.; Hoyt, J. M.; Krska, S. W.; Tudge, M. T.; Chirik, P. J.  Cobalt Precursors for the High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation CatalystsScience 2013, 342, 1076-1080.
  26. Spahn, E.; Albright, A.; Shevlin, M.; Pauli, L.; Pfaltz, A.; Gawley, R. E.  Double-Asymmetric Hydrogenation Straegy for the Reduction of 1,1-Diaryl Olefins Applied to an Improved Synthesis of CuIPhEt, a C2-Symmetric N-Heterocyclic CarbenoidJ. Org. Chem. 2013, 78, 2731-2735.
  27. Stewart, G. W.; Shevlin, M.; Yamagata, A. D. G.; Gibson, A. W., Keen, S. P.; Scott, J. P.  Enantioselective Synthesis of β-Aryloxycarboxylic Esters via Asymmetric Hydrogenation of β-Aryloxy-α,β-Unsaturated EstersOrg. Lett. 2012, 14, 5440-5443.
  28. Mangion, I. K.; Ruck, R. T.; Rivera, N.; Huffman, M. A,; Shevlin, M.  A Concise Synthesis of a β-Lactamase InhibitorOrg. Lett. 2011, 13, 5480-5483.
  29. Shevlin, M.  Sulfate Additives Generate Robust and Highly Active Palladium Catalysts for the Cyanation of Aryl ChloridesTetrahedron Lett. 2010, 51, 4833-4836.
  30. Mangion, I. K.; Nwamaba, I. K.; Shevlin, M.; Huffman, M. A.  Iridium-Catalyzed X-H Insertions of Sulfoxonium YlidesOrg. Lett. 2009, 11, 3566-3569.
  31. Ruck, R. T.; Huffman, M. A.; Kim, M. M.; Shevlin, M.; Kandur, W. V.; Davies, I. W.  Palladium-Catalyzed Tandem Heck Reaction / C-H Functionalization - Preparation of Spiro-Indane-OxindolesAngew. Chem. Int. Ed. 2008, 120, 4789-4792.
  32. Ghosh, A.; Shevlin, M.  The Development of Titanium Enolate-Based Aldol Reactions.  In Modern Aldol Reactions Vol. 1: Enolates, Organocatalysis, Biocatalysis, and Natural Product Synthesis.  Marhwald, Ranier, Ed.; Wiley-VCH, 2004, pp 63-125.
  • Dumas, A. M.; Scott, J. P.; Shevlin, M.; Liu, Z.; Chung, K. Y. L.; Xu, F.; Meng, D.; Gudipati, V.  Methods of Preparing Hydroxylamine Derivatives Useful in the Preparation of Anti-Infective Agents.  U.S. Patent 10,472,345, Nov 12, 2019.
  • Chung, J. Y. L.; Kassim, A.; Limanto, J.; Shevlin, M.; Maligres, P. E.; DiRocco, D. A.; Dropinski, J. F.; Mathew, R.; Ji Chen, Y. N.; Sherer, E.; Reibarkh, M.; Klapars, A.; Hyde, A.; Zultanski, S.; Moment, A.; Simmons, B.; Davis, T. A.; Wright, T. J.; Calanria, R.; Campeau, L.-C.  Process for Making Chloro-Substituted Nucleoside Phosphoramidate Compounds.  U.S. Patent 10,214,554, Feb 26, 2019.
  • Isaacs, R. C. A.; Thompson, W. J.; Williams, P. D.; Su, D.-S.; Venkatraman, S.; Embrey, M. W.; Fisher, T. E.; Wai, J. S.; Dubost, D. C.; Ball, R. G.; Choi, E. J.; Pei, T.; Trice, S. L.; Campbell, N.; Maddess, M.; Maligres, P. E.; Shevlin, M.; Song, Z. J.; Steinhuebel, D. P.; Strotman, N. A.; Yin, J.  HIV Integrase Inhibitors.  U.S. Patent 8,513,234, Aug 20, 2013.
  • Blizzard, T. A.; Chen, H.; Gude, C.; Hermes, J. D.; Imbriglio, J. E.; Kim, S.; Wu, J. Y.; Ha, S.; Motko, C. J.; Mangion, I.; Rivera, N.; Ruck, R. T.; Shevlin, M.  Beta-Lactamase Inhibitors.  U.S. Patent 8,487,093, Jul 16, 2013.
Seminars and Short Courses:
  • Shevlin, M.  Asymmetric Hydrogenation: Historical Perspectives, Mechanistic Insights, Modern Practices, and Future Directions. Presented at 30th International Symposium on Chirality, Princeton, NJ, 10 Jun 2018.
  • Shevlin, M.  High-Throughput Experimentation for Chemists: Large Arrays of Rationally Designed Experiments for Solving Complex Chemical Problems. Presented at WuXi AppTec, Tianjin, China (virtually), 15 Apr 2021; Merck & Co., Inc., Boston, MA, 1 Nov 2018; Merck & Co., Inc., West Point, PA, 29 Oct 2018; Northwestern University, 19 Oct 2018; Merck & Co., Inc., Kenilworth, NJ, 12 Oct 2018; Merck & Co., Inc., Rahway, NJ, 12 Sep 2018; Seoul National University, 5 Jul 2017; Korea Advanced Institute of Science and Technology, 4 Jul 2017; Pohang University of Science and Technology, 3 Jul 2017; Shanghai SynTheAll Pharmaceuticals Co., 23 Jun 2017; Shanghai Institute of Organic Chemistry, 22 Jun 2017; Emory University, 29 Nov 2016; Takasago International Corporation, 20 Jul 2016; Nagoya University, 19 Jul 2016; Kyoto University, 15 Jul 2016; University of Tokyo, 8 Jul 2016; University of California-Berkeley, 28 Mar 2016; University of Illinois-Chicago, 1 Oct 2015; Princeton University, 27 Apr 2015; Merck & Co., Inc., Rahway, NJ, 14 Nov 2014.
Short Talks and Posters:
  • Shevlin, M.  High Throughput Experimentation-Enabled Discovery and Development of Cobalt-Catalyzed Asymmetric Hydrogenation. Presented at 3rd Small Molecule Activation Conference, Nassau, Bahamas, 21 Feb 2019.
  • Shevlin, M.  Industrially Relevant Cobalt-Catalyzed Asymmetric Hydrogenation: A Highly Efficient Synthesis of Levetiracetam. Presented at 9th Chicago Organic Symposium, Chicago, IL, 20 Oct 2018.
  • Shevlin, M.  Industrially Relevant Cobalt-Catalyzed Asymmetric Hydrogenation: A Highly Efficient Synthesis of Levetiracetam. Presented at 19th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, Jeju, South Korea, 26 Jun 2017.
  • Shevlin, M.  Industrially Relevant Cobalt-Catalyzed Asymmetric Hydrogenation: A Highly Efficient Synthesis of Levetiracetam.  Presented at JST-Princeton University Base Metal Catalysis Symposium, 2 Sep 2016.
  • Shevlin, M.  Nickel-Catalyzed Asymmetric Hydrogenation.  Presented at 20th International Symposium on Homogeneous Catalysis, Kyoto, Japan, 14 Jul 2016.
  • Shevlin, M.  Homogeneous Nickel-Catalyzed Asymmetric Hydrogenation of Olefins.  Presented at International Chemical Congress of Pacific Basin Societies, Honolulu, HI, 2015.
  • Shevlin, M.  Base Metal Catalyzed Asymmetric Hydrogenation.  Presented at 19th International Symposium on Homogeneous Catalysis, Ottawa, ON, 2014.
  • Shevlin, M.  Adventures in Transition Metal Catalysis: High Throughput Experimentation-Enabled Reaction Discovery, Development, and Optimization.  Presented at 246th ACS National Meeting, Indianapolis, IN, 2013.
  • Shevlin, M.  Remarkable Effect of Sulfate Additives on the Palladium-Catalyzed Cyanation of Aryl Chlorides.  Presented at the 240th ACS National Meeting, Boston, MA, 2010.
  • US EPA Presidential Green Chemistry Challenge Award for Greener Synthetic Pathways, 2017
  • American Chemical Society Technical Achievement in Organic Chemistry Award, 2013
  • Merck Special Achievement Award, 2014, 2013, 2011
  • National Science Foundation Graduate Research Fellowship Honorable Mention, 2003
  • University of Illinois at Chicago University Fellowship, 2001, 2003
  • Rose-Hulman Institute of Technology William Albert Noyes, Sr. Award in Chemistry, 2001
  • Rose-Hulman Institute of Technology Presidential Scholarship, 1998-2001
  • Indiana Academic Honors Diploma
  • Attended Indiana Academy for Science, Mathematics, and Humanities
  • Second Place, Internet Raytracing Competition, May-June 2004
  • Superintendent, Vanderburgh County 4-H Aerospace Program
  • President, Rose-Hulman Chess Club
  • Second Place, Rose-Hulman Campus Chess Tournament, 2001
  • Recording Studio Director, WMHD radio station
  • First Place, State American Chemical Society Advanced Examination, 1998
  • First Place, Indiana Junior Academy of Science Examination, 1998
  • First Place, State Junior Engineering and Technical Society Team Examination, 1998
  • 10 year 4-H member with 29 champion and 8 reserve champion awards
  • Club Master, American Contract Bridge League
  • Team Captain, Indiana Academy Solar Car Team

References available upon request.

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